PEDIATRICS Vol. 98 No. 1 July 1996, pp. 163
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Letter To The Editor

Cheston M. Berlin Jr MD1 and William Banner Jr MD, PhD2

1 AAP Committee on Drugs, Milton S. Hershey Medical Center, Hershey, PA 17033
2 AAP Committee on Drugs, St Francis Hospital, Tulsa, OK 74136

We appreciate the information from Rhoads and Rogan regarding the treatment of lead-exposed children (TLC) trial that will include children down to a blood lead of 20 µg/dL. The issue of thresholds for detectable effects of lead remains controversial and is less relevant in the face of the purpose of this trial: ie, will the benefits of treatment outweigh the risks associated with chelation therapy? This large-scale trial using body surface area will be useful to demonstrate any benefit of that approach over weight-based calculations.




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