PEDIATRICS Vol. 98 No. 1 July 1996, pp. 133-135
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Ceftriaxone Choledocholithiasis

Frank M. Robertson MD1, Timothy M. Crombleholme MD, FAAP1, Sarah E. Barlow MD2, Menno Verhave MD2, and Daniel Brown MD3

1 Division of Pediatric Surgery
2 Division of Pediatric Gastroenterology, Tufts University School of Medicine and the Floating Hospital, New England Medical Center, Boston, MA 02111
3 Department of Pediatrics, Portsmouth Regional Hospital, Portsmouth, NH 03801

Ceftriaxone is a broad-spectrum, third-generation cephalosporin. The formation of biliary sludge and cholelithiasis after ceftriaxone administration has been reported and is thought by many to be a benign process.1-3 Despite this, cholecystectomy has been performed in symptomatic patients who have received ceftriaxone.3,4 This complication of ceftriaxone therapy is not widely appreciated in the gastroenterology and surgical literature. We report the documented case of ceftriaxone choledocholithiasis.

CASE REPORT

A 9-year-old boy who 4 weeks before admission was treated for open head trauma was referred for evaluation of abdominal pain and cholelithiasis. The patient sustained a comminuted, depressed skull fracture of the left frontal area with underlying cerebral laceration from being kicked in the head by a horse.

Submitted on August 15, 1995
Accepted on October 3, 1995