PEDIATRICS Vol. 98 No. 1 July 1996, pp. 130-133
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Histiocytic Necrotizing Lymphadenitis With Autoimmune Phenomena and Meningitis in a 14-Year-Old Girl

Jason S. Debley MD1, David J. Rozansky MD1, Michael L. Miller MD1, Ben Z. Katz MD1, and Marianne E. Greene MD2

1 Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, Chicago, IL 60614
2 Department of Pathology, Northwestern University Medical School, Children's Memorial Hospital, Chicago, IL 60614

Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a disorder of lymph nodes originally described by Kikuchi1 and Fujimoto2 in 1972. Since 1982 this disorder has been increasingly recognized in the United States and worldwide, with the most extensive analyses of the disease presented by Dorfman et al.3-5 There has been little discussion of this entity in the pediatric literature.

The most common presentation of necrotizing lymphadenitis includes fever and painless cervical lymphadenopathy. Patients may also present with weight loss, nausea, vomiting, diarrhea, chills, or diaphoresis. On occasion, myalgias, arthralgias, malar or butterfly rash, hepatomegaly, and splenomegaly have been noted.3

Submitted on February 6, 1995
Accepted on September 22, 1995




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