PEDIATRICS Vol. 97 No. 5 May 1996, pp. 782
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Acute Isoniazid Neurotoxicity in an Urban Hospital

Mirzada Pasic Kurbasic MD, MSc1 and J. Thomas Badgett PhD, MD1

1 Division of General Pediatrics, Department of Pediatrics, School of Medicine, University of Louisville, Louisville, KY 40292

In the May issue of Pediatrics, Dr Shah and collaborators pointed out an increased incidence of isoniazid (INH) neurotoxicity.1

At the Children's University Hospital in Tuzla, Bosnia, and Herzegovina, four patients (age range, 6 to 9 years) were admitted for INH neurotoxicity in a 15-month period.2 None of them had liver dysfunction or metabolic disturbance, such as acidosis or hyperglycemia. All intoxications were accidental. Patients responded well to high doses of intravenous pyridoxine, including two with seizures and coma that had been unresponsive to treatment with phenobarbital and diazepam, respectively, before admission.