PEDIATRICS Vol. 97 No. 5 May 1996, pp. 779-780
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Reappraisal of Lytic Cocktail/Demerol, Phenergan, and Thorazine (DPT) for the Sedation of Children

Bruce R. Parks PhD1 and S. Robert Snodgrass MD2

1 Clinical Pharmacy Practice, School of Pharmacy, University of Mississippi, Medical Center, Jackson, MS 39216
2 Division of Pediatric Neurology, University of Mississippi Medical Center, Jackson, MS 39216

We were disappointed in the AAP statement by the Committee on Drugs entitled Reappraisal of Lytic Cocktail/Demerol, phenergan, and Thorazine (DPT) for the Sedation of Children (Pediatrics 1995;95:598-602). The Committee identified many problems associated with this traditional drug mixture but refused to bite the bullet and acknowledge that its time is past. Their unqualified endorsement of ketamine and propofol use by nonanesthesiologists also concerns us.

The lytic cocktail contains a long-acting opiate with a tendency to activate seizures and two long-acting neuroleptics.


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