PEDIATRICS Vol. 97 No. 3 March 1996, pp. 401-403
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Sweet Syndrome Associated With G-CSF Treatment in a Child With Glycogen Storage Disease Type Ib

BEN ZION GARTY MD1, ITZHAK LEVY MD1, MENACHEM NITZAN MD1, and YIGAL BARAK MD2

1 Department of Pediatrics, Kipper Institute of Pediatric Immunology and Allergy, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva 49202, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
2 Department of Pediatrics, Kaplan Medical Center, Rehovot, Israel

Acute febrile neutrophilic dermatosis (Sweet syndrome) is rare in children and is regularly associated with underlying malignancies or inflammatory diseases. A 5-year-old girl with glycogen storage disease type Ib, neutropenia, and recurrent infections developed characteristic skin eruption of Sweet syndrome after 2 years of granulocyte colony-stimulating factor (G-CSF) therapy. This association points to a possible role of G-CSF-induced granulopoiesis and granulocyte activation in the pathogenesis of Sweet syndrome.

Submitted on December 2, 1994
Accepted on March 22, 1995




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