PEDIATRICS Vol. 96 No. 6 December 1995, pp. 1177
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Correct Dosing of Vancomycin in Infants and Children

Beth A. Logsdon PharmD1, Kelley R. Lee PharmD1, and Fred F. Barrett MD1

1 LeBonheur Children's Medical Center, University of Tennessee, Memphis, Memphis, TN 38103

In accordance with the recent Centers for Disease Control and Prevention guidelines for the use of vancomycin,1 we began uating the indications and dose of vancomycin IV used in our institution. We discovered a large amount of incorrect dosing of vancomycin in infants and children with 30 mg/kg/day (10 mg/kg q8h). This dose has been traced to The Harriet Lane Handbook, 13th edition.2 However, all the references listed in Harriet Lane on page 561 recommend the standard dosing of vancomycin, 40 mg/kg/day (10 mg/kg q6h).