PEDIATRICS Vol. 96 No. 6 December 1995, pp. 1153-1155
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Abman, S. H.
Right arrow Articles by Kinsella, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abman, S. H.
Right arrow Articles by Kinsella, J. P.

Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: The Physiology Matters

Steven H. Abman MD1 and John P. Kinsella MD2

1 Section of Pulmonary and Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, The Children's Hospital, Denver, CO 80218-1088
2 Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, The Children's Hospital, Denver, CO 80218-1088

Pulmonary Medicine, B-395, The Children's Hospital, 1056 East Nineteenth Avenue, Denver, CO 80218-1088

The ability of inhaled nitric oxide (iNO) to acutely lower pulmonary vascular resistance (PVR) and improve oxygenation in diverse clinical settings suggests that iNO therapy may provide a unique tool to expand our current armamentariurn in treating various cardiopulmonary disorders, including persistent pulmonary hypertension of the newborn (PPHN). Treatment of severe PPHN has been limited in part by the lack of a selective pulmonary vasodilator that effectively lowers PVR without adverse effects on systemic arterial pressure, cardiac performance, or intrapulmonary shunt. In 1992, two articles were published in Lancet which reported that iNO can improve oxygenation in neonates with severe PPHN without lowering systemic pressure.1,2

Submitted on October 6, 1995
Accepted on October 6, 1995




This article has been cited by other articles:


Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
N V Subhedar and N J Shaw
Changes in oxygenation and pulmonary haemodynamics in preterm infants treated with inhaled nitric oxide
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 1997; 77(3): 191F - 197.
[Abstract] [Full Text]