PEDIATRICS Vol. 96 No. 6 December 1995, pp. 1126-1131
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Using Characteristic Changes in Laboratory Values to Assist in the Diagnosis of Hemorrhagic Shock and Encephalopathy Syndrome

David S. Jardine MD1 and Susan L. Bratton MD1

1 Department of Anesthesiology, Children's Hospital and Medical Center, University of Washington, Seattle

Objectives. (1) To determine whether the laboratory abnormalities in hemorrhagic shock encephalopathy syndrome (HSES) follow a characteristic pattern of evolution; and (2) to describe the clinical characteristics and outcome of this group of children.

Design. Retrospective review of hospital records.

Setting. Pediatric intensive care unit in an academic children's hospital.

Patients. Seventeen children who received the diagnosis of HSES.

Measurements. (1) To support the diagnosis of HSES, the following laboratory tests were obtained: creatine phosphokinase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, anemia, thrombocytopenia, coagulation abnormalities, and a metabolic acidosis; and (2) patient characteristics at the time of admission and during the illness and patient outcome were recorded.

Results. The median time for laboratory abnormalities in HSES to reach the most aberrant levels was 1.2 to 1.4 days. After reaching maximal deviation, the laboratory values gradually returned to normal. The severity of laboratory abnormalities was not predictive of mortality. All patients were comatose, had seizures, and required fluid resuscitation. Respiratory failure occurred in 12 (71%) of 17 patients. Vasopressor infusions were used for 8 (47%). Viral cultures were performed in 15 patients and were positive in 8 (53%). Eleven (64%) patients survived.

Conclusions. The laboratory abnormalities that are characteristic of HSES follow a distinctive pattern of evolution during the course of the illness. Although the sensitivity, specificity, and predictive value of this pattern of laboratory abnormalities are not known, it might provide a useful tool in diagnosing HSES and excluding other illnesses. Viral illness is common in HSES. The severity of illness and mortality in this group of patients is similar to other descriptions of HSES.

Submitted on May 20, 1994
Accepted on November 28, 1994




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