PEDIATRICS Vol. 96 No. 3 September 1995, pp. 592-594
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Deloria, M. A.
Right arrow Articles by Edwards, K. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Deloria, M. A.
Right arrow Articles by Edwards, K. M.

Association of Reactions After Consecutive Acellular or Whole-Cell Pertussis Vaccine Immunizations

Maria A. Deloria BS1, William C. Blackwelder PhD1, Michael D. Decker MD, MPH2, Janet A. Englund MD3, Mark C. Steinhoff MD4, Michael E. Pichichero MD5, Margaret B. Rennels MD6, Edwin L. Anderson MD7, and Kathryn M. Edwards MD8

1 Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD
2 Departments of Preventive Medicine, Medicine (Infectious Diseases), Vanderbilt University School of Medicine, Nashville, TN
3 Departments of Microbiology and Immunology and Pediatrics, Baylor College of Medicine, Houston, TX
4 Departments of International Health and Pediatrics, Johns Hopkins University, Baltimore, MD
5 Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY
6 Department of Pediatrics and the Center for Vaccine Development, University of Maryland School of Medicine, Baltimore
7 Department of Medicine, St Louis University School of Medicine
8 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN

Objective. To evaluate the relative frequency of adverse reactions after initial and subsequent immunizations among infants receiving primary immunization with acellular (DTaP) or whole-cell (DTP) pertussis vaccine with diphtheria and tetanus combined.

Methods. We examined the occurrence of common reactions in 2127 infants within 48 hours after immunization at 2, 4, and 6 months with one of 13 DTaP or with Lederle DTP (WCL). Data on at least two consecutive immunizations were available for 357 WCL recipients and 1770 DTaP recipients. For these analyses, reactions evaluated included fever of 100.4°F (38°C) or greater, redness of 21 mm or larger, swelling of 21 mm or larger, moderate or severe pain, moderate or severe fussiness, loss of appetite, drowsiness, and vomiting.

Results. With one exception, reactions were approximately 1.5 to 8 times more likely to occur in WCL recipients if the same reaction had been observed at the previous immunization (the single exception was redness after the second immunization). Both initial and repeated reactions were less likely in DTaP than in WCL recipients. As with WCL recipients, risks of repeated reactions in DTaP recipients were higher than the risks of initial reactions (from 2.5 to 24 times as high).

Conclusion. Reactions after a second or third immunization with either WCL or DTaP vaccine are more likely to occur in infants who had the same reaction after the preceding immunization. Absolute risks of repeated reactions tended to be lower after DTaP vaccine than after the WCL vaccine.




This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
M. E. Pichichero, J. R. Casey, A. B. Francis, S. M. Marsocci, M. Murphy, W. Hoeger, and C. Cleary
Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment When Preceded by Different 5-Dose DTaP/DTwP Schedules
Clinical Pediatrics, September 1, 2006; 45(7): 613 - 620.
[Abstract] [PDF]

Home page
 PediatricsHome page
T. S. DuVernoy, M. M. Braun, and the VAERS Working Group
Hypotonic-Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998
Pediatrics, October 1, 2000; 106(4): 52e - 52.
[Abstract] [Full Text]

Home page
 PediatricsHome page
M. E. Pichichero, K. M. Edwards, E. L. Anderson, M. B. Rennels, J. A. Englund, D. E. Yerg, W. C. Blackwelder, D. L. Jansen, and B. D. Meade
Safety and Immunogenicity of Six Acellular Pertussis Vaccines and One Whole-Cell Pertussis Vaccine Given as a Fifth Dose in Four- to Six-Year-Old Children
Pediatrics, January 1, 2000; 105(1): e11 - e11.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. E. Pichichero, M. A. Deloria, M. B. Rennels, E. L. Anderson, K. M. Edwards, M. D. Decker, J. A. Englund, M. C. Steinhoff, A. Deforest, and B. D. Meade
A Safety and Immunogenicity Comparison of 12 Acellular Pertussis Vaccines and One Whole-Cell Pertussis Vaccine Given as a Fourth Dose in 15- to 20-Month-Old Children
Pediatrics, November 1, 1997; 100(5): 772 - 788.
[Abstract] [Full Text] [PDF]