PEDIATRICS Vol. 96 No. 2 August 1995, pp. 407
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REDUCTION OF MATERNAL-INFANT TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I WITH ZIDOVUDINE TREATMENT

Mary E. Paul MD1, William T. Shearer MD, PhD1, and Joseph A. Church MD2

1 Houston, TX
2 Los Angeles, CA

Zidovudine, given in the regimen described above, significantly reduced the risk of maternal-infant HIV transmission in pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during pregnancy, with few short-term side effects of therapy.