PEDIATRICS Vol. 96 No. 2 August 1995, pp. 382-383
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Randolph, C.
Right arrow Articles by Kaplan, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Randolph, C.
Right arrow Articles by Kaplan, M.

SERUM SICKNESS-LIKE REACTIONS TO CEFACLOR: ROLE OF HEPATIC METABOLISM AND INDIVIDUAL SUSCEPTIBILITY

Christopher Randolph MD1 and Michael Kaplan MD2

1 Waterbury, CT
2 Los Angeles, CA

The findings indicate that cefaclor-associated serum sickness-like reaction may be a unique adverse drug reaction that requires biotransformation of the parent drug and may be associated with inherited defects in the metabolism of reactive intermediates. The condition can be retrospectively confirmed with an in vitro lymphocyte-based cytotoxicity assay. This assay is specific for cefaclor and does not cross-react with cephalexin.