PEDIATRICS Vol. 96 No. 2 August 1995, pp. 380
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SYNTHETIC FOOD COLORING AND BEHAVIOR: A DOSE-RESPONSE EFFECT IN A DOUBLE-BLIND, PLACEBO-CONTROLLED, REPEATED-MEASURES STUDY

Christopher Randolph MD1

1 Waterbury, CT

Behavioral changes in irritability, restlessness, and sleep disturbance are associated with the ingestion of tartrazine in some children. A dose-response effect was observed.