PEDIATRICS Vol. 95 No. 5 May 1995, pp. 717-721
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lieb, L. E.
Right arrow Articles by Ward, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lieb, L. E.
Right arrow Articles by Ward, J. W.

Unrecognized Human Immunodeficiency Virus Type 1 Infection in a Cohort of Transfused Neonates: A Retrospective Investigation

Loren E. Lieb MPH1, Thomas M. Mundy MD2, Dennis Goldfinger MD2, Samuel H. Pepkowitz MD2, Philip A. Brunell MD2, M. Blake Caldwell MD3, and John W. Ward MD3

1 The HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, Atlanta, Georgia
2 Cedars-Sinai Medical Center, Los Angeles, Atlanta, Georgia
3 Division of HIV/AIDS, Centers for Disease Control and Prevention, Atlanta, Georgia

Objective. To retrospectively identify unrecognized human immunodeficiency virus type 1 (HIV-1) infection among a cohort of children transfused as neonates before donated blood was routinely screened for HIV-1 antibody.

Methods. Records at a large, private, metropolitan hospital were reviewed to identify children who were transfused as neonates between January 1980 and March 1985 and discharged alive from the hospital. Multiple data sources were used to locate these children. Parents or guardians were contacted, and their children were offered HIV-1 antibody testing and physical examination.

Results. Of the 775 children identified as having received transfusions during the project period, 644 (83%) were located, and 443 (69%) were evaluated for HIV-1 infection. Among those evaluated, 33 (7%) had antibody to HIV-1, including 14 whose infections had not been previously diagnosed. At the time of enrollment, 13 children infected with HIV-1 were asymptomatic an average of 63 months after transfusion.

Conclusion. HIV-1 antibody testing should be considered for all children, regardless of clinical status, who were transfused before routine blood donor screening was implemented in March 1985, particularly in areas with a high incidence of acquired immunodeficiency syndrome during those years.

Submitted on May 10, 1994
Accepted on August 12, 1994




This article has been cited by other articles:


Home page
 PediatricsHome page
Committee on Pediatric AIDS
Identification and Care of HIV-Exposed and HIV-Infected Infants, Children, and Adolescents in Foster Care
Pediatrics, July 1, 2000; 106(1): 149 - 153.
[Abstract] [Full Text]

Home page
 CLIN PEDIATRHome page
T. M. Courville, B. Caldwell, and P. A. Brunell
Lack of Evidence of Transmission of HIV-1 to Family Contacts of H1V-1 Infected Children
Clinical Pediatrics, March 1, 1998; 37(3): 175 - 178.
[Abstract] [PDF]