PEDIATRICS Vol. 95 No. 5 May 1995, pp. 688-692
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McEvoy, C.
Right arrow Articles by Durand, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McEvoy, C.
Right arrow Articles by Durand, M.

Neonatal Pulmonary Mechanics and Oxygenation After Prophylactic Amnioinfusion in Labor: A Randomized Clinical Trial

Cindy McEvoy MD1, Smeeta Sardesai MD1, Charles Macri MD2, Richard Paul MD2, and Manuel Durand MD1

1 Division of Neonatal-Perinatal Medicine, Los Angeles County and University of Southern California Medical Center, Department of Pediatrics, University of Southern California School of Medicine, Los Angeles
2 Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles

Objective. Amnioinfusion has been reported to improve the perinatal outcome of pregnancies complicated by decreased amniotic fluid volume, but detailed information on its possible adverse effects on neonatal pulmonary mechanics and oxygenation is not available.

Study design. We evaluated 42 infants with birth weights of 2600 to 4320 g and gestational ages of 36 to 44 weeks, who were born to mothers enrolled in a prospective, randomized trial of amnioinfusion for oligohydramnios in labor. Maternal entry criteria were gestational age 36 weeks or older, estimated fetal weight more than 2500 g, oligohydramnios defined as an amniotic fluid index of 5 cm or less, and a normal fetal heart rate pattern. Evaluation of pulmonary mechanics and oxygen saturation (SaO2) was done with the infants breathing room air between birth and day 3 of life. Transpulmonary pressure, flow, and tidal volume were recorded simultaneously, and pulmonary resistance and lung compliance were calculated. SaO2 was measured for 30 minutes with the Nellcor N-200 oximeter and IBM computer oximetry software.

Results. Evaluation of the data revealed no significant difference between the two groups for tidal volume, lung compliance, pulmonary resistance, or work of breathing. There were no differences between the two groups in the number of desaturation episodes or in percent of desaturations to less than 90%, 85%, or 80% SaO2.

Conclusion. Prior studies have shown amnioinfusion to improve perinatal outcome. Our findings demonstrate that amnioinfusion for oligohydramnios in labor does not adversely affect neonatal pulmonary mechanics or oxygenation.

Submitted on September 14, 1993
Accepted on August 9, 1994




This article has been cited by other articles:


Home page
 PediatricsHome page
C. McEvoy, D. Schilling, P. Spitale, D. Peters, J. O'Malley, and M. Durand
Decreased Respiratory Compliance in Infants Less Than or Equal to 32 Weeks' Gestation, Delivered More Than 7 Days After Antenatal Steroid Therapy
Pediatrics, May 1, 2008; 121(5): e1032 - e1038.
[Abstract] [Full Text] [PDF]