PEDIATRICS Vol. 95 No. 3 March 1995, pp. 350-354
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The Surprisingly High Acceptability of Low-Efficacy Vaccines for Otitis Media: A Survey of Parents Using Hypothetical Scenarios

Lori L. Wischnack MD1, Robert M. Jacobson MD2, Gregory A. Poland MD3, Steven J. Jacobsen MD, PhD4, Jay M. Harrison MS5, and Paul A. Murtaugh PhD6

1 Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, Department of Family Medicine, Department of Pediatric and Adolescent Medicine
2 Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, Section of Community Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine
3 Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, Section of General Internal Medicine, Department of Internal Medicine
4 Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, Section of Clinical Epidemiology, Department of Health Sciences Research; of the Mayo Clinic, Rochester, MN
5 Department of Statistics, University of Florida, Gainesville, FL
6 Department of Statistics, Oregon State University, Corvallis OR

Objective. To determine parental thresholds for accepting vaccines for otitis media prevention given tradeoffs of efficacy, adverse effects, and administration mode.

Method. We interviewed 601 randomly selected parents with children 0 through 6 years of age presenting to our community pediatric clinic. For each of five hypothetical vaccines, which varied administration mode from nasal spray to two injections and adverse effects from mild to severe, parents indicated the lowest number of otitis media episodes that the vaccine had to prevent in the next 6 months for them to accept the vaccine.

Results. About half the parents would accept any one of the vaccines if it would prevent three or more infections in the next 6 months. When the vaccine would prevent one episode of otitis media over the next 6 months, 33% of parents would accept the medial vaccine (one injection in the thigh, with some children getting a red, sore injection site and a few having a fever of le102°F for one day). Seventeen percent accepted a vaccine requiring two injections (influenza vaccine-like) or having increased adverse effects (pneumococcal vaccine-like) despite the vaccine only preventing one episode of otitis media over the next 6 months. No substantial differences in these proportions were found when compared among groups by reason-for-visit, recent occurrence of otitis media, or a history of recurrent otitis media in a sibling.

Conclusion. Many parents will accept low efficacy vaccines for otitis media prevention. Parental acceptance does not vary with the child's otitis media experience but does vary with severity of adverse effects and administration mode of the vaccine.

Submitted on January 25, 1994
Accepted on June 14, 1994




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