PEDIATRICS Vol. 95 No. 2 February 1995, pp. 276-280
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Fatal Hantavirus Pulmonary Syndrome in an Adolescent

Ali S. Khan MD1, Thomas G. Ksiazek DVM, PhD1, Sherif R. Zaki MD, PhD1, Stuart T. Nichol PhD1, Pierre E. Rollin MD1, Cj Peters MD1, Rima F. Khabbaz MD1, James E. Cheek MD, MPH2, Larry A. Shireley MS, MPH3, Stephen L. McDonough MD3, Thomas K. Welty MD, MPH4, and Diana Kuklinski REHS5

1 Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333
2 Indian Health Service, HQW, Albuquerque, NM 87110
3 North Dakota State Department of Health and Consolidated Laboratories, Bismarck, ND 58505
4 Epidemiology Program, Aberdeen Area Indian Health Service, Rapid City, SD 57702
5 Environmental Health, Devils Lake Sioux Tribe, Fort Totten, ND 58335

Hantavirus pulmonary syndrome (HPS) is a recently recognized viral zoonosis characterized by a febrile prodrome progressing to severe noncardiogenic pulmonary edema.1-4 This syndrome is caused by at least three newly described hantaviruses: the first, Sin Nombre virus, is the Southwestern hantavirus that caused an outbreak of respiratory failure during the summer of 1993; the second, Black Creek Canal virus, caused a case of HPS in Florida; and the third hantavirus was identified in lung tissue from a patient in Louisiana. Diagnosis is by enzyme-linked immunosorbent assay (ELISA) serology with elevated immunoglobulin M (IgM) titers against heterologous and homologous hantaviral antigens, positive immunohistochemistry on formalin-fixed tissue, or reverse transcriptase-polymerase chain reaction (RT-PCR) amplification of hantaviral nucleotide sequence from frozen tissue.

Submitted on May 9, 1994
Accepted on June 9, 1994




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M. M. Ramos, G. D. Overturf, M. R. Crowley, R. B. Rosenberg, and B. Hjelle
Infection With Sin Nombre Hantavirus: Clinical Presentation and Outcome in Children and Adolescents
Pediatrics, August 1, 2001; 108 (2): e27 - e27.
[Abstract] [Full Text] [PDF]