PEDIATRICS Vol. 94 No. 6 December 1994, pp. 823
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A PLEA FOR SIMPLICITY AND LARGE SAMPLE SIZE

"Most [clinical] trials would be of much greater scientific value if they collected ten times less data, both at entry and during follow-up, and were therefore much larger.

Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. In: Warren KS, Mosteller F, eds. Doing More Good Than Harm: The Evaluation of Health Care Interventions."