PEDIATRICS Vol. 93 No. 6 June 1994, pp. 951-955
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumar, P.
Right arrow Articles by Delaney-Black, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, P.
Right arrow Articles by Delaney-Black, V.

Post Extracorporeal Membrane Oxygenation Single Photon Emission Computed Tomography (SPECT) as a Predictor of Neurodevelopmental Outcome

Praveen Kumar MD1, Mary P. Bedard MD1, Seetha Shankaran MD1, and Virginia Delaney-Black MD1

1 Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI

Objective. To determine the incidence and site of single photon emission computed tomography scan (SPECT) abnormalities in survivors of neonatal extracorporeal membrane oxygenation and to evaluate the efficacy of SPECT scan as a predictor of neurodevelopmental outcome in these infants.

Setting. Tertiary care neonatal intensive care unit in Detroit, MI.

Patient population. Survivors of neonatal extracorporeal membrane oxygenation who had a SPECT scan of the brain performed after decannulation and before their discharge from the neonatal intensive care unit were included if they had at least 12 months of follow-up in our developmental assessment clinic.

Outcome measures. The neurological outcome was reported as normal, suspect, and abnonnal on the basis of neurological examination and developmental milestones. The developmental outcome was assessed by Bayley mental development index or McCarthy general cognitive index scores.

Results. A total of 59 patients met study criteria. SPECT scan abnormalities were noted in 45 (76%) infants. Global hypoperfusion was the most frequent abnormality followed closely by bilateral focal perfusion defects. The distribution of perfusion abnormalities was not significantly different for right and left hemispheres. Among 14 infants with normal SPECT scans, 13 infants had normal neurological outcome and all had a normal developmental outcome. Of the 45 infants with an abnormal SPECT scan, 7 infants had an abnormal neurological outcomes and 4 infants had an abnormal developmental outcome. SPECT scan abnormalities had no significant correlation with neurodevelopmental outcome of these infants.

Conclusion. Although a normal SPECT scan was more likely to predict a normal neurodevelopmental outcome, an abnormal SPECT scan did not predict an abnormal outcome in these infants.

Submitted on June 10, 1993
Accepted on November 24, 1993




This article has been cited by other articles:


Home page
 J Child NeurolHome page
L. A. O'Tuama, D. P. Dickstein, R. Neeper, and G. G. Gascon
Topical Review: Functional Brain Imaging in Neuropsychiatric Disorders of Childhood
J Child Neurol, April 1, 1999; 14(4): 207 - 221.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
R. D. Sheth
Frequency of Neurologic Disorders in the Neonatal Intensive Care Unit
J Child Neurol, September 1, 1998; 13(9): 424 - 428.
[Abstract] [PDF]