PEDIATRICS Vol. 93 No. 2 February 1994, pp. 234-240
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Neuron-Specific Enolase and Myelin Basic Protein: Relationship of Cerebrospinal Fluid Concentrations to the Neurologic Condition of Asphyxiated Full-Term Infants

Alfredo Garcia-Alix MD1, Fernando Cabañas MD1, Adelina Pellicer MD1, Tom A. Stinis MD, PhD1, Jose Quero MD1, and Angel Hernanz MD2

1 Department of Pediatrics, Division of Neonatology, La Paz Children's Hospital, Autonoma University of Madrid, 28046 Madrid, Spain
2 Department of Biochemistry, La Paz Children's Hospital, Autonoma University of Madrid, 28046 Madrid, Spain

Objective. We questioned whether neuron-specific enolase (NSE) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) in the first 72 hours of life are correlated with the neurologic condition of asphyxiated full-term infants in the neonatal period and at 1 year of age.

Patients and methods. Sixty-nine asphyxiated infants were studied with serial neurologic examination, cranial ultrasonography, and neurologic follow-up. CSF samples were obtained by lumbar puncture at 12 and 72 hours of life. NSE was measured by enzyme immunoassay, and MBP was measured by radioimmunoassay.

Results. Twenty infants had no neonatal encephalopathy and 49 exhibited different stages of encephalopathy. NSE and MBP concentrations in CSF at 12 and 72 hours of life were related to the degree of neonatal encephalopathy. Neither NSE nor MBP levels were correlated with any perinatal factors. Infants with documented brain injury had the highest concentrations of both NSE and MBP. The concentrations of these two biochemical markers at both 12 and 72 hours correlated with adverse outcome (death or cerebral palsy at 1 year). Based on a receiver operating characteristics curve analysis for any given specificity, NSE at 12 hours was a more accurate marker than MBP at either 12 or 72 hours for distinguishing infants with motor impairment at age 1 year from infants with normal outcome at the same age.

Conclusions. Our findings suggest that NSE and MBP are reliable biochemical markers for early estimates of hypoxic-ischemic brain damage in asphyctic full-term newborns, NSE being superior to MBP.

Submitted on February 5, 1993
Accepted on July 22, 1993




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