PEDIATRICS Vol. 92 No. 5 November 1993, pp. 715-717
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Glucocorticoid-Responsive Hypotension in Extremely Low Birth Weight Newborns

HAROLD J. HELBOCK MD1, ROBERT M. INSOFT MD1, and FELIX A. CONTE MD1

1 Cardiovascular Research Institute, Dept of Pediatrics, Divisions of Neonatology and Endocrinology, University of California, San Francisco

The maintenance of normal basal secretion and the ability to produce a stress-induced rise in cortisol secretion are critical to homeostasis. Glucocorticoids have a multiplicity of effects, among which are maintenance of glucose homeostasis, facilitation of free water clearance, and maintenance of vascular tone. Patients with glucocorticoid deficiency manifest hypotension which is resistant to the effects of volume expansion and vasopressors. This form of hypotension has been attributed to (1) renin substrate deficiency, (2) a direct effect of glucocorticoids, and/or (3) the lack of cortisol inhibition of nitric oxide and/or prostaglandin I2 synthesis, both potent vasodilators.1,2

At birth, complex changes occur in both the secretion and metabolism of steroids; these result in maintenance of appropriate postnatal cortisol production.3

Submitted on February 10, 1993
Accepted on April 28, 1993




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