PEDIATRICS Vol. 92 No. 5 November 1993, pp. 710-714
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Safety and Efficacy of a Topical Anesthetic for Neonatal Circumcision

Kathleen B. Weatherstone MD1, Lynn B. Rasmussen RN, NNP1, Allen Erenberg MD1, Emily M. Jackson 1, Katherine S. Claflin MD1, and Richard D. Leff PharmD1

1 From the KU Children's Center, University of Kansas Medical Center, Kansas City, KS

Objective. Circumcision is a common neonatal surgical procedure routinely performed without the use of anesthesia. The purpose of this study was to evaluate the safety and efficacy of topical lidocaine cream as an anesthetic for circumcision.

Methods. Thirty newborns were studied in a randomized, double-blind, placebo-controlled study; 15 received a topical 30% lidocaine cream and 15 received the cream base alone. Vital signs were recorded, and preoperative and postoperative serum beta-endorphin and lidocaine concentrations were measured. A videotape of the newborn was used to score behavioral changes.

Results. Comparisions of the vital signs precircumcision and postcircumcision showed no differences between the placebo and treatment groups, with the exception of mean systolic blood pressure, which significantly increased in the placebo-treated newborns (P < .05). Serum beta-endorphin concentrations increased postoperatively in 11 of 15 subjects receiving placebo, but decreased or remained unchanged in 10 of 15 subjects receiving lidocaine (P = .03, Fisher's exact test). When stress-related behaviors in the precircumcision and post-circumcision periods were compared, the mean increase in their occurrence was greater in the placebo than in the treatment group. There was no significant absorption of lidocaine as measured in the serum.

Conclusion. Topical application of a 30% lidocaine cream as used in this study may be a safe and efficacious anesthetic for circumcision.

Key Words: neonate • circumcision • lidocaine • anesthetic • beta-endorphin

Submitted on February 5, 1993
Accepted on May 10, 1993




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