PEDIATRICS Vol. 92 No. 3 September 1993, pp. 459-460
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Acute Flank Pain and Reversible Renal Dysfunction Associated With Nonsteroidal Anti-inflammatory Drug Use

SARA C. MCINTIRE MD1, RONALD C. RUBENSTEIN MD, PHD1, J. CARLTON GARTNER JR MD1, NISAN GILBOA MD1, and DEMETRIUS ELLIS MD1

1 Dept of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used in adults with well-known toxic renal effects.1 They are used less often in pediatric patients, and the reports of serious nephrotoxic effects are infrequent. We report two cases of acute flank pain and reversible renal dysfunction associated with use of NSAIDs.

CASE REPORTS

F.M.

A healthy 14-year-old boy took three doses of flurbiprofen (100 mg per dose every 12 hours) to relieve bilateral ankle pain, which he experienced after playing hockey and skiing; 2 days later bilateral costovertebral angle tenderness developed. At a local hospital a urinalysis showed 30 mg/dL protein and 1 to 2 red blood cells and 2 to 3 white blood cells per high-power field (hpf).

Submitted on January 20, 1993
Accepted on March 31, 1993




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