PEDIATRICS Vol. 91 No. 6 June 1993, pp. 1217-1218
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Which Is the Most Appropriate Dosage of Liposomal Amphotericin-B (AmBisome) for the Treatment of Fungal Infections in Infants of Very Low Birth Weight?

L. PEREIRA DA SILVA MD1, J. M. VIDEIRA AMARAL MD1, and N. CORDEIRO FERREIRA MD, PHD1

1 Department of Pediatrics, Faculty of Medical Sciences, Universidade Nova de Lisboa, Neonatal Intensive Care Unit of Dona Estefånia, Pediatric Hospital, Lisbon, Portugal

To the Editor.—

Lackner et al1 report on the excellent efficacy and lack of toxicity of 1 to 5 mg/kg per day of liposomal Amphotericin-B (AmBisome) administered to two infants of very low birth weight with disseminated fungal infection.

We agree with the authors when they say that success in the treatment of two cases does not allow extrapolation of the same therapeutic schedule to an infants with identical multisystemic immaturity.

We would like to report two cases from our own clinical experience with distinct characteristics.