PEDIATRICS Vol. 91 No. 5 May 1993, pp. 989-993
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Spectrum of Limb Disruption Defects Associated With Chorionic Villus Sampling

BARBARA K. BURTON MD1, CHARLENE J. SCHULZ MS2, and LAURENCE I. BURD MD3

1 Depts of Pediatrics and Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago, Michael Reese Hospital and Medical Center, Chicago
2 Michael Reese Hospital and Medical Center
3 Dept of Obstetrics and Gynecology, University of Illinois College of Medicine, Michael Reese Hospital and Medical Center

A number of recent publications have suggested an increased incidence of transverse limb anomalies,1,2 the hypoglossia-hypodactylia syndrome,1 and cavernous hemangiomas3 in infants born to mothers who had undergone chorionic villus sampling (CVS) in the first trimester of pregnancy. We previously reported 4 CVS-related cases of transverse limb anomalies2 and since have examined 10 additional cases. The purpose of this report is to describe the spectrum of abnormalities observed in these 14 cases. We believe that the findings in these patients support an association between CVS and limb abnormalities by demonstrating that the type of anomaly associated with CVS is a very specific one that is uncommonly observed in the general population.

Submitted on October 19, 1992
Accepted on December 16, 1992




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