PEDIATRICS Vol. 91 No. 3 March 1993, pp. 583-586
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Recent Improvement in Outcome Using Transcatheter Embolization Techniques for Neonatal Aneurysmal Malformations of the Vein of Galen

Deborah M. Friedman MD1, Rajiv Verma MD1, Mary Madrid MA, RN2, Alejandro Berenstein MD2, and Jeffrey H. Wisoff MD3

1 From the Division of Pediatric Cardiology, New York University Medical Center, New York, NY.
2 From the Division of Neuroradiology, New York University Medical Center, New York, NY.
3 From the Division of Pediatric Neurosurgery, New York University Medical Center, New York, NY.

Vein of Galen malformations may present as congestive heart failure in the neonate and are usually fatal if untreated. Early studies using transcatheter embolization techniques, in a series of 22 patients, had a 50% mortality rate and a 37% incidence of severe mental retardation in survivors. Modifications of embolization techniques and neonatal care have improved the outlook in a more recent series of 11 patients. The diagnosis was established within 3 days of life in 91% of the cases. No mortality occurred, and 6 of the patients were functionally normal at up to 30 months' follow-up. Although two patients had severe neurologic deficits and/or a seizure disorder, only one case was possibly temporally associated with the embolization procedure. Some developmental delay was noted in one other patient. These improvements result, in part, from modifications of the treatment protocol, including earlier diagnosis, avoidance of digoxin, improvement in the application of newer microcatheters and acrylic polymers (n-butylcyanoacrylate), avoidance of overly aggressive neurosurgical procedures, and the use of stable central vascular access for total parenteral nutrition accompanying other general improvements in neonatal care.

Key Words: vein of Galen • transcatheter embolization • neonates • congestive heart failure

Submitted on April 30, 1992
Accepted on September 10, 1992




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