PEDIATRICS Vol. 90 No. 6 December 1992, pp. 1008-1009
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agr-Fetoprotein and Hypothyroidism in Infants

G. J. MIZEJEWSKI 1 and K. A. PASS 1

1 Wadsworth Center for Laboratories & Research, New York State Department of Health, Albany, NY 12201-0509

To the Editor.—

We recently have documented a relationship between serum agr-fetoprotein (AFP) and congenital hypothyroidism (CH) in the newborn period. Previous studies in our laboratory and others had reported a relationship between elevated serum AFP and elevated thyroid-stimulating hormone (TSH)/low thyroxine T4 in newborns and infants in the first few months of life.1-4 The New York State Newborn Screening Program for CH routinely screens more than 300 000 specimens per year diagnosing 120 to 140 confirmed cases of CH annually.


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 Arch Pediatr Adolesc MedHome page
I. D. Schwartz, A. I. Freeman, and J. A. Grunt
Serum Concentrations of Alpha-fetoprotein in Children With Primary Hypothyroidism
Arch Pediatr Adolesc Med, February 1, 1994; 148(2): 225 - 227.
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