PEDIATRICS Vol. 90 No. 5 November 1992, pp. 678-680
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Recombinant Erythropoietin as Treatment for the Late Hyporegenerative Anemia of Rh Hemolytic Disease

Robin K. Ohls MD1, Robert D. Christensen MD1, and Paul E. Wirkus MD2

1 From the Divisions of Human Development and Aging and Neonatology, University of Utah School of Medicine, Salt Lake City
2 From the Department of Pediatrics, University of Utah School of Medicine, Salt Lake City

Infants with Rh hemolytic disease can develop a "late" anemia characterized by low serum concentrations of erythropoietin but erythroid progenitors that remain highly erythropoietin-responsive. Erythropoietin administration was evaluated in two patients as an alternative to transfusion. Reticulocyte counts increased after 5 days of treatment, and hematocrits increased after 10 days. Neither patient received erythrocyte transfusions following erythropoietin therapy.

Key Words: erythropoietin • Rh hemolytic disease • anemia • neonates

Submitted on February 25, 1992
Accepted on April 10, 1992




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