PEDIATRICS Vol. 90 No. 4 October 1992, pp. 628-630
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Primary Human Herpesvirus-6 Infection (Exanthem Subitum) in the Newborn

SHINJI KAWAGUCHI MD1, SADAO SUGA MD1, TORU KOZAWA MD1, TOSHIHIKO NAKASHIMA MD2, TETSUSHI YOSHIKAWA MD2, and YOSHIZO ASANO MD2

1 Departments of Pediatrics, Toyokawa City Hospital, Toyokawa, Aichi, Japan
2 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

Human herpesvirus-6 (HHV-6) is a newly identified herpesvirus and a causative agent of exanthem subitum (roseola infantum).1 Serologic studies have shown that a substantial proportion of adults are positive for the antibody to HHV-6 and that infection with the virus occurs during the first year of life.2 The virus persists throughout adult life and frequently is shed in the saliva. 3,4 However, the disease does not usually develop during the first months of life. It is probable that maternally acquired antibody to HHV-6 protects infants from the disease.2 In this paper we discuss a 21-day-old boy with exanthem subitum, who had HHV-6 viremia in the febrile stage of his illness and had a seroconversion to the virus.

Submitted on February 24, 1992
Accepted on April 24, 1992




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[Abstract] [Full Text]