PEDIATRICS Vol. 90 No. 3 September 1992, pp. 424-429
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brandes, J. M.
Right arrow Articles by Gershoni-Baruch, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brandes, J. M.
Right arrow Articles by Gershoni-Baruch, R.

Growth and Development of Children Conceived by In Vitro Fertilization

Joseph M. Brandes MD1, Joseph Itzkovits MD, DSc1, Anat Scher PhD2, Miriam Sarid MA2, Israel Thaler MD3, and Ruth Gershoni-Baruch MD4

1 From the Departments of Obstetrics and Gynecology, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
2 From the Department of School of Education, Haifa University, Haifa, Israel
3 From the Departments of Obstetrics and Gynecology, Israel
4 From the Department of The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel and the Department of Pediatrics, Rambam Medical Center, Israel

To assess the physical and mental development of infants born after in vitro fertilization (IVF), we performed a general physical and developmental examination (Bayley and Stanford-Binet scales) on a cohort of 116 IVF children, conceived and born at our institution between February 1985 and March 1989, and on 116 non-IVF matched controls. Study and control groups were each composed of 66 singletons, 19 pairs of twins and 4 sets of triplets, whose age at examination ranged from 12 to 45 months. The developmental indices of IVF infants were within the normal range and did not differ from those of their matched controls. The indices were positively correlated to gestational age, birth weight, head circumference at birth and at examination, and mother's education. Mean birth weight, gestational age, and birth weight percentile of IVF infants were lower than the mean of the healthy population. Mean percentiles of weight and length at examination (mean age 22.4 months) were equally low but did not differ from those of the matched controls. However, mean percentiles of head circumference at birth and at examination compare well with the normal mean, both in IVF and control groups. Twins and triplets (IVF and controls) had significantly lower physical and mental indices as compared to singletons.

Key Words: in vitro fertilization • growth • mental development

Submitted on May 4, 1992
Accepted on May 11, 1992




This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
K.J. Middelburg, M.J. Heineman, A.F. Bos, and M. Hadders-Algra
Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review
Hum. Reprod. Update, May 1, 2008; 14(3): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Mau Kai, K. M. Main, A. Nyboe Andersen, A. Loft, M. Chellakooty, N. E. Skakkebaek, and A. Juul
Serum Insulin-Like Growth Factor-I (IGF-I) and Growth in Children Born after Assisted Reproduction
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4352 - 4360.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A. Pinborg
IVF/ICSI twin pregnancies: risks and prevention
Hum. Reprod. Update, November 1, 2005; 11(6): 575 - 593.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Hansen, C. Bower, E. Milne, N. de Klerk, and J. J.Kurinczuk
Assisted reproductive technologies and the risk of birth defects--a systematic review
Hum. Reprod., February 1, 2005; 20(2): 328 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Koivurova, A.-L. Hartikainen, U. Sovio, M. Gissler, E. Hemminki, and M.-R. Jarvelin
Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF
Hum. Reprod., November 1, 2003; 18(11): 2328 - 2336.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Pinborg, A. Loft, L. Schmidt, and A. N. Andersen
Morbidity in a Danish National cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families
Hum. Reprod., June 1, 2003; 18(6): 1234 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Bonduelle, I. Ponjaert, A.V. Steirteghem, M.-P. Derde, P. Devroey, and I. Liebaers
Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF
Hum. Reprod., February 1, 2003; 18(2): 342 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Golombok, A. Brewaeys, M.T. Giavazzi, D. Guerra, F. MacCallum, and J. Rust
The European study of assisted reproduction families: the transition to adolescence
Hum. Reprod., March 1, 2002; 17(3): 830 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J Pediatr PsycholHome page
C.-S. Hahn
Review: Psychosocial Well-Being of Parents and Their Children Born After Assisted Reproduction
J. Pediatr. Psychol., December 1, 2001; 26(8): 525 - 538.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. F. Muller, A. Verhoeff, M. J. Mantel, F. H. de Jong, and A. Berghout
Decrease of Free Thyroxine Levels after Controlled Ovarian Hyperstimulation
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 545 - 548.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
C. Patrat, J.-P. Wolf, S. Epelboin, J.-N. Hugues, F. Olivennes, P. Granet, J.-R. Zorn, and P. Jouannet
Pregnancies, growth and development of children conceived by subzonal injection of spermatozoa
Hum. Reprod., September 1, 1999; 14(9): 2404 - 2410.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
S W D'Souza, E Rivlin, J Cadman, B Richards, P Buck, and B A Lieberman
Children conceived by in vitro fertilisation after fresh embryo transfer
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 1997; 76(2): 70F - 74.
[Abstract] [Full Text]

Home page
 NEJMHome page
P. J. Neumann, S. D. Gharib, and M. C. Weinstein
The Cost of a Successful Delivery with in Vitro Fertilization
N. Engl. J. Med., July 28, 1994; 331(4): 239 - 243.
[Abstract] [Full Text]