PEDIATRICS Vol. 90 No. 2 August 1992, pp. 216-220
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Varicella in Pediatric Renal Transplant Recipients

Ruth Lynfield MD1, John T. Herrin MBBS, FRACP1, and Robert H. Rubin MD2

1 From the Children's Service, Massachusetts General Hospital, Boston
2 From the Department of Medicine, Massachusetts General Hospital, Boston

As of November 1991, 8 of 83 children who had received renal transplants at Massachusetts General Hospital since January 1979 required admission for primary variceila. All 8 had cutaneous manifestations of disease, and 4 had evidence of visceral disease. Three of these 8 children received varicella zoster immune globulin (VZIG) after exposure to varicella; in the remaining children, exposure was not revealed until symptoms were present. All 8 children were treated with high-dose intravenous acyclovir. Two children died of complications of varicella infecfion, including 1 child who received VZIG on the day of exposure to varicella. Neither VZIG prophylaxis nor treatment with intravenous acyclovir offers complete protection against severe varicella infection to immunosuppressed children who have received organ transplants. A high priority should be given to the evaluation of alternative treatments, such as vaccination to the varicella virus, which could be administered to susceptible transplant candidates, preferably prior to transplantation.

Key Words: varicella • pediatric renal transplant

Submitted on August 16, 1991
Accepted on January 15, 1992




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