PEDIATRICS Vol. 90 No. 1 July 1992, pp. 102-104
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Recurrent Ovarian Cysts in Childhood: Diagnosis of McCune-Albright Syndrome by Bone Scan

LAUREN S. FRISCH MD1, KENNETH C. COPELAND MD2, and PAUL A. BOEPPLE MD1

1 Pediatric and Reproductive Endocrine, Units, Massachusetts General Hospital, Boston, Massachusetts 02114
2 Department of Pediatrics, University of Vermont College of Medicine, Burlington, Vermont 05401-2296

During the past decade, it has become clear that precocious puberty is a complex disorder with multiple pathophysiologic causes. Although gonadotropin-releasing hormone (GnRH)-dependent mechanisms account for the vast majority of precocious puberty in girls, GnRH-independent processes play an important role in a minority of patients. The recent availability of specific therapies for both GnRH-dependent and GnRH-independent precocious puberty has made it increasingly important for pediatricians to distinguish between these two subsets.1,2 Although most patients with precocious puberty neatly fall into one or the other subset, a significant minority of patients may present a diagnostic challenge even after an extensive evaluation is undertaken.

Submitted on July 25, 1991
Accepted on December 12, 1991


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