PEDIATRICS Vol. 9 No. 3 March 1952, pp. 286-289
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CHRONIC HEMOLYTIC ANEMIA IN A WHITE CHILD DUE TO THALASSEMIA AND SICKLEMIA

With a Genealogic Survey

CHARLES F. WASSERMAN M.D.1, V. RAE PHELPS PH.D.1, and A. J. HERTZOG M.D.1

1 The Departments of Pediatrics and Pathology of Touro Infirmary and the Tulane University of Louisiana at New Orleans.

The authors have described the second case in the United States of chronic hemolytic anemia resulting from the genetic factors for sicklemia and thalassemia minor in combination. A complete hematologic study of 37 relatives of the propositus is presented. The four possible theories, as proposed by earlier investigators, which may explain the severe clinical manifestations, are given.

Submitted on September 7, 1951