PEDIATRICS Vol. 9 No. 1 January 1952, pp. 27-31
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ADRENOCORTICOTROPIC HORMONE IN THE THERAPY OF RETROLENTAL FIBROPLASIA

JONATHAN T. LANMAN M.D.1, LOREN P. GUY M.D.2, and JOSEPH DANCIS M.D.2

1 The Children's Medical Service, Bellevue Hospital, and the Department of Pediatrics, New York University College of Medicine, New York City., Fellow of the National Foundation for Infantile Paralysis.
2 The Children's Medical Service, Bellevue Hospital, and the Department of Pediatrics, New York University College of Medicine, New York City.

Five premature infants thought to be developing retrolental fibroplasia were treated early, vigorously and persistently with ACTH from a single Armour lot. Activity of the ACTH employed was evidenced in each case by physiologic changes in the recipient.

One of the five treated patients died during therapy. The mode of death and possible relationship to ACTH administration are discussed.

Retrolental fibroplasia progressed in the four remaining treated cases to cicatrix formation behind the lens.

ACTH as employed in this study was an ineffective therapeutic agent in retrolental fibroplasia.

Submitted on August 1, 1951