PEDIATRICS Vol. 89 No. 5 May 1992, pp. 936-941
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Apolipoprotein A-I, A-II, B, C-II, and C-III in Children with Insulin-dependent Diabetes Mellitus

Najah Al Muhtaseb PhD1, Abdul Razak Al Yousuf FRCP2, and J. S. Bajaj FRCPE1

1 From the Department of Medicine and Center for Diabetes, Faculty of Medicine, Kuwait
2 From the Department of Medicine and Center for Diabetes, Faculty of Medicine, Kuwait; A.R.A.Y. died after submission of the manuscript

This study was conducted to determine whether changes in the levels of plasma apolipoproteins (apo) A-I, A-II, B, C-II, and C-III, along with cholesterol and triglycerides, could provide additional information on these parameters in relation to the control of glycemia. Plasma and lipoprotein lipids and apolipoprotein levels were measured in 123 insulin-dependent diabetic childern (4- to 12-years-old), classified into good, fair, and poor diabetic control based on HbAlc and fructosamine levels, and in 62 comparable healthy controls. Total cholesterol, very low density lipoprotein cholesterol, and low density lipoprotein cholesterol, as well as total triglycenides, very low density lipoprotein, low density lipoprotein, and high density lipoprotein (HDL) triglycerides, and apo B and apo C-III were increased significantly in children with fair and poor diabetic control. While in diabetic children with good control, only very low density lipoprotein cholesterol was elevated significantly compared with healthy control subjects. Conversely, the levels of cholesterol in HDL, HDL2, HDL3, and apo A-I were decreased significantly in the three diabetic groups, but apo A-II and apo C-II did not change. We conclude that in children with insulin-dependent diabetes mellitus, abnormalities in plasma lipid, lipoprotein, and apolipoprotein levels occur, the extent of which depends on the degree (extent) of glycemic control (the poorer the control the more substantial the abnormality). We suggest that measurement of apo C-III level along with apo B and apo A-I in these patients may be a sensitive indicator to alterations in glycemic control.

Key Words: Apolipoprotein A-I • apolipoprotein B • apolipoprotein C-III • lipoproteins • diabetic children

Submitted on April 23, 1991
Accepted on August 15, 1991




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