PEDIATRICS Vol. 89 No. 5 May 1992, pp. 882-887
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pichichero, M. E.
Right arrow Articles by Disney, F. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pichichero, M. E.
Right arrow Articles by Disney, F. A.

Acellular Pertussis Vaccination of 2-Month-Old Infants in the United States

Michael E. Pichichero MD1, Anne B. Francis MD1, Mark M. Blatter MD2, Keith S. Reisinger MD2, John L. Green MD1, Steven M. Marsocci MD1, and Frank A. Disney MD1

1 From the University of Rochester Medical Center, Department of Pediatrics, Rochester, New York 14642; Elmwood Pediatric Group, Rochester, NY 14620
2 From the Pittsburgh Pediatric Associates, Pittsburgh, PA 15241

This is the first study in children from the United States that evaluates the immunogenicity of and adverse reactions to the Connaught/Biken two-component acellular pertussis vaccine compared with whole-cell pertussis vaccine when given as a primary immunization series at 2, 4, and 6 months of age. Three hundred eighty infants were studied; 285 received acellular diphtheria-tetanus toxoids-pertussis (DTP (ADTP)) and 95 received whole-cell DTP (WDTP). Following the third dose, ADTP vaccination produced higher antibody responses than WDTP to lymphocytosis-promoting factor (enzyme-linked immunosorbent assay IgG geometric mean titer (GMT) = 131 vs 9 and Chinese hamster ovary cell assay GMT = 273 vs 16) and to filamentous hemagglutinin (IgG GMT = 73 vs 10) (all P < .0001). Agglutinin responses were higher in WDTP compared with ADTP recipients (GMT = 50 vs 37; P=.02). Local reactions were fewer for all three doses following ADTP vaccination. Fever, irritability, drowsiness, anorexia, vomiting, and unusual crying all occurred less frequently in ADTP compared with WDTP recipients for one or more of the three doses. We conclude that this two-component ADTP vaccine when given as a primary series produces greater immunogenicity and fewer adverse effects than the currently licensed WDTP vaccine.

Key Words: Acellular pertussis vaccine • whole-cell pertussis vaccine • lymphocytosis-promoting factor • filamentous hemagglutinin • immunogenicity

Submitted on December 17, 1990
Accepted on June 24, 1991