PEDIATRICS Vol. 89 No. 2 February 1992, pp. 354
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Varicella Vaccine Reflux

C. J. WHITE MD1

1 Department of Clinical Research, Merck Sharpe & Dohme Research Laboratories, West Point, Pennsylvania 19486

In Reply.—

Herpes zoster (shingles) is the dermatomal skin eruption resulting from the reactivation of varicella-zoster virus remaining latent in posterior sensory root ganglia following childhood chickenpox (the primary infection with varicella-zoster virus). Since the live attenuated varicella-zoster virus contained in the vaccine replicates in the vaccinee similar to the wild-type virus, establishment of latency is possible for the attenuated strain. Several publications have addressed latency of the attenuated virus following immunization.

Two studies have examined the incidence of zoster in children with acute lymphoblastic leukemia (ALL) following immunization with live attenuated varicella-zoster virus.


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