PEDIATRICS Vol. 89 No. 1 January 1992, pp. 133-137
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Controlled Trial of Nebulized Albuterol in Children Younger Than 2 Years of Age With Acute Asthma

Lea Bentur MD1, Gerard J. Canny MD1, Michael D. Shields MD1, Eitan Kerem MD1, Joseph J. Reisman MD1, Khoulood Fakhoury MD1, Linda Pedder MD1, Henry Levison MD1, and Suzanna Schuh MD2

1 From the Pulmonary Division and Emergency Department, Toronto, Ontario, Canada
2 From the Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada

To determine the response to nebulized beta2 agonist, 28 children younger than 2 years of age who visited the emergency department during an episode of acute asthma were studied. Each subject had a previous history of recurrent wheezing episodes. They were randomly assigned to receive two administrations of either nebulized albuterol (0.15 mg/kg per dose) or placebo (normal saline) with oxygen, 1 hour apart. After two nebulizations, the albuterol-treated patients had a greater improvement in clinical status (respiratory rate, degree of wheezing and accessory muscle use, total clinical score, and arterial oxygen saturation) than the placebo group. None of the patients in the albuterol group experienced a decrease of arterial oxygen saturation of ge2%. It is conduded that a trial of nebulized beta2 agonists is warranted in the treatment of acute asthma in infants and young children.

Key Words: albuterol • asthma • infants

Submitted on March 25, 1991
Accepted on August 12, 1991


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