PEDIATRICS Vol. 88 No. 6 December 1991, pp. 1144-1147
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Cardiac Sequelae of Kawasaki Disease in Japan: Statistical Analysis

Yosikazu Nakamura MD1, Yasuyuki Fujita MD1, Masaki Nagai MD1, Hiroshi Yanagawa MD1, Yoshio Imada MD2, Sumio Okawa MD2, Tomisaku Kawasaki MD3, and Hirohisa Kato MD4

1 From the Department of Public Health, Jichi Medical School, Minamikawachi-machi, Tochigi, Japan
2 From the Department of Pediatrics, Japan Red Cross Medical Center, Shibuya-ku, Tokyo
3 From the Kawasaki Disease Research Information Center, Chiyoda-ku, Tokyo
4 From the Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume-shi, Fukuoka, Japan

The proportions of Kawasaki disease patients with cardiac sequelae in Japan were analyzed using nationwide survey data from the 6frac12-year period July 1982 through December 1988. Of 46 864 cases of Kawasaki disease reported in the surveys, 7637 or 16.3% had cardiac sequelae such as dilation or stenosis of coronary arteries, myocardial infarction, and valvar lesions 1 month on more after onset. The prevalence of cardiac sequelae was particularly high in males, infants younger than 1 year, and children older than 5 years of age. In sequential observation, there was no correlation between the prevalence of cardiac sequelae and periods of high or low incidence of the disease. The prevalence of cardiac sequelae overall declined steadily over the observation period, perhaps as a consequence of increasing use of intravenous gamma globulin. However, children older than the age of 5 years manifested increasing prevalence of cardiac sequelae over the observation period, probably as a result of lower rates of intravenous gamma globulin administration.

Key Words: Kawasaki disease • cardiac sequelae

Submitted on October 22, 1990
Accepted on December 19, 1990




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