Neurologic Outcome After Electroencephalographically Proven Neonatal Seizures
1 The Division of Neurology, The Children's Hospital of Philadelphia and the Departments of Neurology and Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia
Infants in whom neonatal seizures were confirmed by randomly recorded ictal electroencephalographic (EEG) tracings were retrospectively examined to determine their global neurologic outcome and the specific frequency of epilepsy, development delay, and cerebral palsy. Perinatal and postnatal clinical and EEG variables were also examined for their relevance to the neurologic outcome. Forty infants with EEG documented seizures of diverse etiologies were studied. The 27 survivors were followed up at a mean of 31 months. The outcome was unfavorable in 70%. The rate of epilepsy was 56%, of developmental delay 67%, and of cerebral palsy 63%. The etiology of seizures was an important factor influencing the outcome. Other clinical factors that showed a significant relationship with global or specific aspects of the neurologic outcome included the age at the onset of seizures, birth weight, and neurologic examination results. The EEG parameters that significantly predicted the neurologic outcome were interictal EEG background, increased seizure frequency, and decreased seizure duration.
Key Words: neonatal seizures • electroencephalogram • neurologic outcome • epilepsy • cerebral palsy
Submitted on June 29, 1990
Accepted on October 23, 1990
CiteULike 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Pisani, L. Sisti, and S. Seri A Scoring System for Early Prognostic Assessment After Neonatal Seizures Pediatrics, October 1, 2009; 124(4): e580 - e587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pisani, C. Copioli, C. Di Gioia, E. Turco, and L. Sisti Neonatal Seizures: Relation of Ictal Video-Electroencephalography (EEG) Findings With Neurodevelopmental Outcome J Child Neurol, April 1, 2008; 23(4): 394 - 398. [Abstract] [PDF]
|
|
|
|
|
|
R. L. Khan, M. Lahorgue Nunes, L. F. Garcias da Silva, and J. C. da Costa Predictive Value of Sequential Electroencephalogram (EEG) in Neonates With Seizures and Its Relation to Neurological Outcome J Child Neurol, February 1, 2008; 23(2): 144 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Pisani, C. Cerminara, C. Fusco, and L. Sisti Neonatal status epilepticus vs recurrent neonatal seizures: Clinical findings and outcome Neurology, December 4, 2007; 69(23): 2177 - 2185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dlugos and J. I. Sirven Prognosis of neonatal seizures: "It's the etiology, Stupid" or is it? Neurology, November 6, 2007; 69(19): 1812 - 1813. [Full Text] [PDF]
|
|
|
|
|
|
L. G.M. van Rooij, L. S. de Vries, S. Handryastuti, D. Hawani, F. Groenendaal, A. C. van Huffelen, and M. C. Toet Neurodevelopmental Outcome in Term Infants With Status Epilepticus Detected With Amplitude-Integrated Electroencephalography Pediatrics, August 1, 2007; 120(2): e354 - e363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Guillet and J. Kwon Seizure Recurrence and Developmental Disabilities After Neonatal Seizures: Outcomes Are Unrelated to Use of Phenobarbital Prophylaxis J Child Neurol, April 1, 2007; 22(4): 389 - 395. [Abstract] [PDF]
|
|
|
|
|
|
M. R. Liske, C. S. Greeley, D. J. Law, J. D. Reich, W. R. Morrow, H. S. Baldwin, T. P. Graham, A. W. Strauss, A. L. Kavanaugh-McHugh, and W. F. Walsh Report of the Tennessee Task Force on Screening Newborn Infants for Critical Congenital Heart Disease Pediatrics, October 1, 2006; 118(4): e1250 - e1256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tekgul, K. Gauvreau, J. Soul, L. Murphy, R. Robertson, J. Stewart, J. Volpe, B. Bourgeois, and A. J. du Plessis The Current Etiologic Profile and Neurodevelopmental Outcome of Seizures in Term Newborn Infants Pediatrics, April 1, 2006; 117(4): 1270 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Clancy Summary proceedings from the neurology group on neonatal seizures. Pediatrics, March 1, 2006; 117(3 Pt 2): S23 - S27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hahn and D. M. Olson Primer on Neonatal Electroencephalograms for the Neonatologist NeoReviews, August 1, 2004; 5(8): e336 - e349. [Full Text] [PDF]
|
|
|
|
|
|
W. T. Mahle, R. R. Clancy, S. P. McGaurn, J. E. Goin, and B. J. Clark Impact of Prenatal Diagnosis on Survival and Early Neurologic Morbidity in Neonates With the Hypoplastic Left Heart Syndrome Pediatrics, June 1, 2001; 107(6): 1277 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. McBride, N. Laroia, and R. Guillet Electrographic seizures in neonates correlate with poor neurodevelopmental outcome Neurology, August 22, 2000; 55(4): 506 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Evans and M. Levene Neonatal seizures Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1998; 78(1): 70F - 75. [Full Text]
|
|
|
|
 |
|
 K.C.K. Kuban and A. Leviton Cerebral Palsy N. Engl. J. Med., January 20, 1994; 330(3): 188 - 195. [Full Text]
|
|
|
|
|
|
J. W. Newburger, R. A. Jonas, G. Wernovsky, D. Wypij, P. R. Hickey, K. Kuban, D. M. Farrell, G. L. Holmes, S. L. Helmers, J. Constantinou, et al. A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery N. Engl. J. Med., October 7, 1993; 329(15): 1057 - 1064. [Abstract] [Full Text]
|
|
