Factors Influencing the Epidemiology of Helicobacter pylori Infection in Children
1 The Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock
2 Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas
3 Department of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas
The epidemiology of Helicobacter pylori infection was studied in 245 healthy children (between 3 and 20 years of age) who presented for day surgery at Arkansas Children's Hospital. H pylori infection was identified serologically using an enzyme-linked immunosorbent assay to detect the presence of IgG against the high molecular weight, cell-associated antigens of H pylori. Demographic information collected included age, gender, race, family income, type of housing, location of housing, water supply, health status, upper gastrointestinal symptoms, and keeping pets. One hundred eighty-nine white children and 56 black children were studied; 139 were boys and 106 were girls. The data were analyzed by logistic regression analysis. H pylori infection increased significantly with age (P <.05). The frequency of H pylori infection was higher in blacks than whites (P <.01), and this difference remained after adjusting for age, gender, and family income. Family income was used as a measure of socioeconomic class and was an important factor related to infection; the rate of acquisition of H pylori in those children with family income <$5000/year was twice that of those with incomes >$75 000/year (P <.001). There were no significant differences in H pylori infection related to gender, type of housing, location of housing, or source of water supply. It is concluded that the rate of acquisition of H pylori infection increases with age, is higher in blacks than whites, and is inversely related to socioeconomic class.
Key Words: Helicobacter pylori • epidemiology • race • age • socioeconomic group
Submitted on July 30, 1990
Accepted on October 23, 1990
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