PEDIATRICS Vol. 88 No. 2 August 1991, pp. 259-264
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Passive Smoking Alters Lipid Profiles in Adolescents

Joseph Feldman DrPH1, I. Ronald Shenker MD2, Michael Nussbaum MD2, Marc S. Jacobson MD2, Ruth A. Etzel MD, PhD3, Francis W. Spierto PhD3, and David E. Lilienfield MD, MPH, MS, Engin4

1 From the Department of Preventive Medicine, SUNY Health Science Center of Brooklyn, New York
2 From the Division of Adolescent Medicine and Center for Atherosclerosis Prevention, Schneider Children's Hospital of Long Island Jewish Medical Center, the Long Island campus for the Albert Einstein College of Medicine, New Hyde Park, New York
3 Center for Environmental Health and Injury Control, Centers for Disease Control, Atlanta, Georgia
4 From the Division of Environmental and Occupational Medicine, Mt Sinai School of Medicine, New York

Although cigarette smoking is associated with elevation of plasma lipid levels and changes in lipoprotein distribution, it is not known whether passive smoking is associated with an alteration in lipid profiles. The relation between plasma cotinine, a marker of exposure to tobacco smoke, and lipid profiles was studied in healthy adolescents from a suburban New York high school district who were undergoing preparticipation sports physicals. Forty-four percent of the adolescents reported that one or both parents currently smoked. Eleven percent of the adolescents had plasma cotinine concentrations ge2.5 ng/mL, the level considered indicative of exposure. Adolescents with two smoking parents had significantly higher plasma cotinine concentrations after adjustment for other factors than adolescents whose parents did not smoke. Plasma cotinine concentration ge2.5 ng/mL was associated with an 8.9% greater ratio of total cholesterol to high-density lipoprotein cholesterol (P < .003) and a 6.8% lower high-density lipoprotein cholesterol (P < .03). These results suggest that passive smoking, like active smoking, leads to alterations in lipid profiles predictive of an increased risk of atherosclerosis.

Key Words: passive smoking • adolescents • cotinine • lipid profiles • cholesterol

Submitted on July 9, 1990
Accepted on October 20, 1990




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