PEDIATRICS Vol. 87 No. 5 May 1991, pp. 619-622
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Santosham, M.
Right arrow Articles by Pathak, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santosham, M.
Right arrow Articles by Pathak, R.

Role of a Soy-Based Lactose-Free Formula in the Outpatient Management of Diarrhea

Mathuram Santosham MD1, Julius Goepp MD1, Barbara Burns RN1, Raymond Reid MD1, R. Bradley Sack MD1, Crosson O'Donovan MD2, and Radha Pathak MD, MPH2

1 From the Department of International Health, Division of Geographic Medicine, The Johns Hopkins University School of Hygiene and Public Health and The Eudowood Division of Pediatric Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine
2 Francis Scott Key Medical Center, Baltimore, Maryland

The introduction of a soy-based, lactose-free formula during the acute phase of diarrheal illness in infants has been shown to reduce stool output and duration of diarrhea in hospitalized patients. In the United States, most infants with acute diarrhea are treated as outpatients. In the present study, infants with diarrhea who were treated as outpatients were randomly assigned to receive either a soy-based, lactose-free formula alternating with oral rehydration solution from the beginning of therapy ("early feeding") or oral rehydration solution alone for the first 24 hours of therapy, followed by a soy-based, lactose-free formula alternating with oral rehydration solution (control group). Twenty-nine infants were randomly assigned to the early-feeding group and 27 to the control group. Twenty-one (72%) of 29 in the early-feeding group resolved their diarrhea at the end of 48 hours of therapy compared with 12 (44%) of 27 in the group fed oral rehydration solution only (P = .02). It is concluded that the introduction of a soy-based, lactose-free formula from the beginning of therapy for acute diarrhea in children treated as outpatients is safe and may shorten duration of diarrhea while maintaining adequate caloric intake.

Key Words: diarrhea • infants • lactose-free formula • soy-based formula • oral rehydration solution

Submitted on March 2, 1990
Accepted on April 27, 1990




This article has been cited by other articles:


Home page
 PediatricsHome page
J. Bhatia, F. Greer, and and the Committee on Nutrition
Use of Soy Protein-Based Formulas in Infant Feeding
Pediatrics, May 1, 2008; 121(5): 1062 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
I. M. Fayad, M. Hashem, A. Hussein, M. Abou Zikri, M. Abu Zikri, and M. Santosham
Comparison of Soy-Based Formulas With Lactose and With Sucrose in the Treatment of Acute Diarrhea in Infants
Arch Pediatr Adolesc Med, July 1, 1999; 153(7): 675 - 680.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
Committee on Nutrition
Soy Protein-based Formulas: Recommendations for Use in Infant Feeding
Pediatrics, January 1, 1998; 101(1): 148 - 153.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Meyers, A. Sampson, R. Saladino, S. Dixit, W. Adams, and A. Mondolfi
Safety and Effectiveness of Homemade and Reconstituted Packet Cereal-based Oral Rehydration Solutions: A Randomized Clinical Trial
Pediatrics, November 1, 1997; 100(5): e3 - e3.
[Abstract] [Full Text] [PDF]

Home page
 JWatch GeneralHome page
EARLY FEEDING FOR DIARRHEA
Journal Watch (General), May 28, 1991; 1991(528): 2 - 2.
[Full Text]