PEDIATRICS Vol. 87 No. 4 April 1991, pp. 582-583
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Managing Hemangiomas

CAROLE HURVITZ MD1 and ARIE ALKALAY MD2

1 Director, Hematology-Oncology, Associate Director, Clinical Affairs, Department of Pediatrics
2 Neonatologist, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048-1869

To the Editor.—

We read with interest the article, "Management of Alarming Hemangiomas in Infancy: A Review of 25 Cases" by Enjolras et al, in the April, 1990 issue of Pediatrics. We note that all three patients with liver hemangiomas died. We would like to draw your attention to two articles that we have published with regard to treatment of life-threatening hemangiomas with cyclophosphamide.1,2

In our series of four patients, the very large intrahepatic tumor resistant to prednisone in one infant who also had congestive heart failure completely resolved with two courses of cyclophosphamide.