PEDIATRICS Vol. 87 No. 4 April 1991, pp. 549-555
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hofkosh, D.
Right arrow Articles by Bowen, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hofkosh, D.
Right arrow Articles by Bowen, A.

Ten Years of Extracorporeal Membrane Oxygenation: Neurodevelopmental Outcome

Dena Hofkosh MD1, Heidi M. Feldman MD, PhD1, Ann E. Thompson MD2, Robert J. Nozza PhD3, Susan S. Kemp MD4, and A'Delbert Bowen MD4

1 From the Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pennsylvania
2 From the Department of Pediatrics, University of Pittsburgh School of Medicine, and Children's Hospital of Pittsburgh, Pennsylvania and From the Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine
3 Children's Hospital of Pittsburgh, Pennsylvania and From the Department of Otolaryngology, University of Pittsburgh School of Medicine
4 Children's Hospital of Pittsburgh, Pennsylvania, and From the Department of Radiology, University of Pittsburgh School of Medicine

Of the 87 survivors of extracorporeal membrane oxygenation over a 10-year period, 67 participated in a follow-up study which included neurologic examination (n = 67), cognitive testing (n = 67), and audiologic assessment (n = 33). Matched control subjects for those older than 5 years were also evaluated. Outcome was defined as normal for cognitive scores ge85 and normal neurologic examination results, suspect for cognitive scores 70 through 84 or nonfocal neurologic findings such as hypertonia/hypotonia, and abnormal for cognitive scores <70 or abnormal neurologic examination results. Of the 10 school-aged children studied, 9 were normal and there were no differences in mean cognitive scores between subjects and controls (IQ subjects = 109 ± 12 [SD], IQ controls = 107 ± 13). For preschoolers aged 2.7 through 4.11 years, the mean cognitive score was 91 ± 11 and 7 (70%) were normal. For infants 6 through 30 months, the mean cognitive score was 101 ± 22 and 27 (57%) were normal. A total of 7 children (21% of those studied) had abnormal audiologic assessments. Three children demonstrated mild high-frequency and 4 moderately severe high-frequency sensorineural hearing loss which was bilateral in 3 and of undetermined laterality in 1. Abnormal neurodevelopmental outcome was significantly associated with cerebral infarction and chronic lung disease. Outcome was not related to demographic or perinatal variables, illness severity prior to extracorporeal membrane oxygenation, or underlying diagnosis. Neurodevelopmental outcome among survivors of extracorporeal membrane oxygenation in this series is consistent with previous reports of morbidity among neonates with severe respiratory failure treated conventionally.

Key Words: extracorporeal membrane oxygenation • persistent fetal circulation • meconium aspiration syndrome • neurodevelopmental outcome

Submitted on August 13, 1990
Accepted on November 9, 1990




This article has been cited by other articles:


Home page
 PediatricsHome page
A. C. de Mol, L. C. Gerrits, A. F. J. van Heijst, H. Straatman, F. H. J. M. van der Staak, and K. D. Liem
Intravascular Volume Administration: A Contributing Risk Factor for Intracranial Hemorrhage During Extracorporeal Membrane Oxygenation?
Pediatrics, June 1, 2008; 121(6): e1599 - e1603.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
B. J. Fligor, M. W. Neault, C. H. Mullen, H. A. Feldman, and D. T. Jones
Factors Associated With Sensorineural Hearing Loss Among Survivors of Extracorporeal Membrane Oxygenation Therapy
Pediatrics, June 1, 2005; 115(6): 1519 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
A. P. Parish, C. Bunyapen, M. J. Cohen, T. Garrison, and J. Bhatia
Seizures as a Predictor of Long-Term Neurodevelopmental Outcome in Survivors of Neonatal Extracorporeal Membrane Oxygenation (ECMO)
J Child Neurol, December 1, 2004; 19(12): 930 - 934.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. J. Wolfson
The development and use of extracorporeal membrane oxygenation in neonates
Ann. Thorac. Surg., December 1, 2003; 76(6): S2224 - 2229.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
S Ichiba, H M Killer, R K Firmin, S Kotecha, A D Edwards, and D Field
Pilot investigation of hypothermia in neonates receiving extracorporeal membrane oxygenation
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2003; 88(2): F128 - F133.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. Ellington Jr, D. O'Reilly, E. N. Allred, M. C. McCormick, D. L. Wessel, and S. Kourembanas
Child Health Status, Neurodevelopmental Outcome, and Parental Satisfaction in a Randomized, Controlled Trial of Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn
Pediatrics, June 1, 2001; 107(6): 1351 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
K. Rais-Bahrami, A. E. Wagner, C. Coffman, P. Glass, and B. L. Short
Neurodevelopmental Outcome in ECMO Vs Near-Miss ECMO Patients at 5 Years of Age
Clinical Pediatrics, March 1, 2000; 39(3): 145 - 152.
[Abstract] [PDF]