PEDIATRICS Vol. 87 No. 4 April 1991, pp. 519-531
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barkley, R. A.
Right arrow Articles by McMurray, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barkley, R. A.
Right arrow Articles by McMurray, M. B.

Attention Deficit Disorder With and Without Hyperactivity: Clinical Response to Three Dose Levels of Methylphenidate

Russell A. Barkley PhD1, George J. DuPaul PhD1, and Mary B. McMurray MD1

1 From the Departments of Psychiatry, Neurology, and Pediatrics, University of Massachusetts Medical Center, Worcester

The response of 23 children with attention deficit disorder (ADD) with hyperactivity (+H) and 17 children with ADD without hyperactivity (-H) to three doses of methylphenidate (5, 10, and 15 mg twice a day) was evaluated in a triple-blind, placebo-controlled crossover design using parent and teacher ratings of behavior, laboratory tests of ADD symptoms, and behavioral observations during academic performance. Results indicated that the children with ADD+H were rated as having more pervasive behavioral problems at home and more pervasive and severe conduct problems at school than the children with ADD-H. Laboratory tests found the children with ADD+H to be impaired in behavioral inhibition and vigilance whereas children with ADD-H were more impaired in the consistent retrieval of verbally learned material Drug effects were noted on the parent and teacher ratings and on most laboratory measures, with all three doses typically producing significant changes but rarely differing among themselves in effectiveness. The groups were not found to differ significantly on any measures in their response to methylphenidate. However, more children with ADD-H were clinically judged as having either no clinical response (24%) or responding best to the low dose (35%) of medication. In contrast, most ADD+H (95%) children were judged to be positive responders and most were recommended to receive the moderate to high dose (71%).

Key Words: attention deficit disorder • hyperactivity • methylphenidate

Submitted on March 14, 1990
Accepted on May 29, 1990




This article has been cited by other articles:


Home page
 Cereb CortexHome page
A. Diamond
Consequences of Variations in Genes that affect Dopamine in Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i161 - i170.
[Abstract] [Full Text] [PDF]

Home page
 Behav ModifHome page
A. M. McGrath, M. L. Handwerk, K. J. Armstrong, C. P. Lucas, and P. C. Friman
The Validity of the ADHD Section of the Diagnostic Interview Schedule for Children
Behav Modif, May 1, 2004; 28(3): 349 - 374.
[Abstract] [PDF]

Home page
 PediatricsHome page
M. A. Stein, C. S. Sarampote, I. D. Waldman, A. S. Robb, C. Conlon, P. L. Pearl, D. O. Black, K. E. Seymour, and J. H. Newcorn
A Dose-Response Study of OROS Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder
Pediatrics, November 1, 2003; 112(5): e404 - 404.
[Abstract] [Full Text] [PDF]

Home page
 J Learn DisabilHome page
J. Warner-Rogers, A. Taylor, E. Taylor, and S. Sandberg
Inattentive Behavior in Childhood: Epidemiology and Implications for Development
J Learn Disabil, November 1, 2000; 33(6): 520 - 536.
[Abstract] [PDF]

Home page
 J Atten DisordHome page
R. A. Barkley, D. F. Connor, and D. Kwasnik
Challenges to determining adolescent medication response in an outpatient clinical setting: Comparing Adderal and methylphenidate for ADHD
J Atten Disord, August 1, 2000; 4(2): 102 - 113.
[Abstract] [PDF]

Home page
 Canadian Journal of School PsychologyHome page
V. L. Schwean, K. Burt, and D. H. Saklofske
Correlates of Mother-and Teacher-Ratings of Hyperactivity-Impulsivity and Inattention in Children with AD/HD
Canadian Journal of School Psychology, December 1, 1999; 15(1): 43 - 62.
[Abstract] [PDF]

Home page
 CLIN PEDIATRHome page
D. L. Wodrich and S. Landau
School Psychologists: Strategic Allies in the Contemporary Practice of Primary Care Pediatrics
Clinical Pediatrics, October 1, 1999; 38(10): 597 - 606.
[Abstract] [PDF]

Home page
 NEJMHome page
J. Elia, P. J. Ambrosini, and J. L. Rapoport
Treatment of Attention-Deficit-Hyperactivity Disorder
N. Engl. J. Med., March 11, 1999; 340(10): 780 - 788.
[Full Text] [PDF]

Home page
 J PsychopharmacolHome page
E. J. Garland
Reviews : Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats
J Psychopharmacol, January 1, 1998; 12(4): 385 - 395.
[Abstract] [PDF]

Home page
 J Atten DisordHome page
J.B. Hoeppner, J.B. Hale, A.M. Bradley, M. Byrnes, D.L. Coury, L. Lennie, and B.L. Trommer
A clinical protocol for determining methylphenidate dosage levels in ADHD
J Atten Disord, April 1, 1997; 2(1): 19 - 30.
[Abstract]

Home page
 J Atten DisordHome page
G.J. DuPaul, A.D. Anastopoulos, D. Kwasnik, R.A. Barkley, M.B. McMurray, and G. J. DuPaul
Methylphenidate effects on children with Attention Deficit Hyperactivity Disorder: Self-report of symptoms, side-effects, and self-esteem
J Atten Disord, April 1, 1996; 1(1): 3 - 15.
[Abstract]

Home page
 Canadian Journal of School PsychologyHome page
D.H. Saklofske and V.L. Schwean
Standardized Procedures for Measuring the Correlates of ADHD in Children: A Research Program
Canadian Journal of School Psychology, January 1, 1985; 9(1): 28 - 36.
[Abstract] [PDF]