PEDIATRICS Vol. 87 No. 2 February 1991, pp. 235-239
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Neuroleptic Malignant Syndrome: Life-Threatening Complication of Neuroleptic Treatment in Adolescents with Affective Disorder

Paramjit T. Joshi MD1, Joseph A. Capozzoli RN1, and Joseph T. Coyle MD1

1 From the Division of Child Psychiatry, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Neuroleptic malignant syndrome (NMS) is an uncommon, potentially fatal side effect of neuroleptic treatment characterized by hyperthermia, rigidity, rhabdomyolysis, and delerium. In recent clinical studies of adults it was suggested that affective disorder is a risk factor for the development of neuroleptic malignant syndrome. The cases of two adolescents with neuroleptic malignant syndrome who were treated with neuroleptic therapy because of psychotic symptoms in association with primary affective disorders are reported. The occurrence of these cases, as well as the observations in adults, suggests that attention to the primary psychiatric diagnosis is important in neuroleptic usage and that physicians should be vigilant to the occurrence of neuroleptic malignant syndrome in the pediatric population.

Key Words: neuroleptic malignant syndrome • affective disorder

Submitted on December 27, 1989
Accepted on January 18, 1990




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E. B. Ty and A. D. Rothner
Topical Review : Neuroleptic Malignant Syndrome in Children and Adolescents
J Child Neurol, March 1, 2001; 16(3): 157 - 163.
[Abstract] [PDF]