PEDIATRICS Vol. 86 No. 4 October 1990, pp. 594-600
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davis, I. D.
Right arrow Articles by Nevins, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davis, I. D.
Right arrow Articles by Nevins, T. E.

Successful Renal Transplantation Accelerates Development in Young Uremic Children

Ira D. Davis MD1, Pi-Nian Chang PhD1, and Thomas E. Nevins MD1

1 From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis

To examine the impact of renal transplantation on subsequent development of children with chronic renal failure, 37 children undergoing primary renal transplantation at or before 30 months of age whose allograft functioned for at least 1 year were prospectively studied. Psychometric tests were performed an average of 4 months before transplantation; reevaluation was done an average of 14 months after surgery. Comparison of individual pretransplantation and posttransplantation mental development scores in 33 patients, assessed by either Bayley Mental Development Index or Stanford-Binet Intelligence Quotient, revealed an average increase of 12.6 (P < .001). After transplantation, there was a significant improvement in mental performance in 12 of 18 patients (P < .02) from the range of mild delay (Mental Development Index or Stanford-Binet IQ score = 50 to 69) to the range of normal mental development (70). The Bayley Psychomotor Development Index scores were frequently lower than Mental Development Index scores and also increased an average of 14.4 (P < .01) after transplantation in all 12 patients with paired data. Significant individual improvement in occipital-frontal circumference standard deviation score (P < .001) was noted in 24 children after transplantation. It is concluded that successful renal transplantation in young children with chronic renal failure is often associated with significant improvements in cognitive and psychomotor function, as well as improved cephalic growth.

Key Words: chronic renal failure • renal transplantation • mental and motor development • head growth

Submitted on February 12, 1990
Accepted on March 29, 1990




This article has been cited by other articles:


Home page
 CMAJHome page
G. Knoll, S. Cockfield, T. Blydt-Hansen, D. Baran, B. Kiberd, D. Landsberg, D. Rush, E. Cole, and for The Kidney Transplant Working Group of the Can
Canadian Society of Transplantation: consensus guidelines on eligibility for kidney transplantation
Can. Med. Assoc. J., November 8, 2005; 173(10): S1 - S25.
[Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
H N Bawden, P Acott, J Carter, D Lirenman, G W MacDonald, M McAllister, M C McDonnell, S Shea, and J Crocker
Neuropsychological functioning in end-stage renal disease
Arch. Dis. Child., July 1, 2004; 89(7): 644 - 647.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. Wray and R. Radley-Smith
Developmental and Behavioral Status of Infants and Young Children Awaiting Heart or Heart-Lung Transplantation
Pediatrics, March 1, 2004; 113(3): 488 - 495.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
J. D. Hanna, J. W. Foreman, and J. C.M. Chan
Chronic Renal Insufficiency in Infants and Children
Clinical Pediatrics, June 1, 1991; 30(6): 365 - 384.
[PDF]