PEDIATRICS Vol. 86 No. 2 August 1990, pp. 309-312
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Growth Hormone Deficiency in an 8-Year-Old Girl With Human Immunodeficiency Virus Infection

NICHOLAS JOSPE MD1 and KEITH R. POWELL MD1

1 Divisions of Pediatric Endocrinology and Pediatric Infectious Diseases, Department of Pediatrics, University of Rochester Medical School, Rochester, New York

Abnormalities of hypothalamic pituitary function have been reported in adult subjects with human immunodeficiency virus (HIV) infection.1-3 However, endocrine studies in children with HIV infection have failed to disclose significant hormonal abnormalities.4 Indeed, children infected with HIV who were growing poorly were found to have opportunistic infections and lower levels of T-helper cells, but normal growth hormone or insulinlike growth factor 1 concentrations.4

Herein we describe an 8-year-old girl with perinatally acquired HIV infection, growth deceleration, and isolated growth hormone deficiency.

CASE REPORT

This 8 frac12-year-old female child was referred to the pediatric endocrine clinic for evaluation of growth deceleration.

Submitted on November 20, 1989
Accepted on February 5, 1990




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