PEDIATRICS Vol. 86 No. 2 August 1990, pp. 193-196
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bard, H.
Right arrow Articles by Prosmanne, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bard, H.
Right arrow Articles by Prosmanne, J.

Elevated Levels of Fetal Hemoglobin Synthesis in Infants With Bronchopulmonary Dysplasia

Harry Bard MD1 and Janie Prosmanne BSc1

1 From the Research Center, Hôpital Sainte-Justine, Department of Pediatrics, and the University of Montreal, Quebec, Canada

A study was devised to determine whether levels of fetal hemoglobin (HbF) synthesis are elevated in infants with bronchopulmonary dysplasia (BPD) when compared with the levels of HbF synthesis found in normal control infants. Twelve infants with BPD, whose postconceptional ages ranged from 40 to 62 weeks, were studied. The mean (±SD) gestational age and birth weight was 29 ± 1.9 weeks and 1289 ± 376 g, respectively. Elevation infants matched for birth weight, gestational age, and postnatal age served as the control subjects. Blood samples were incubated in an amino acid mixture containing [14C]leucine. The adult hemoglobin and HbF were then separated by column chromatography on diethylaminoethyl-Sephadex. The results demonstrated that the mean (±SD) level of HbF synthesis in infants with BPD was significantly higher than that in the control infants (42.6 ± 22.9% vs 18.8 ± 12.8%; P < .01). When levels of HbF synthesis in the infants with BPD and the control infants were compared with data previously reported in normal infants, 7 of the 12 infants with BPD, but none of the control infants, were synthesizing amounts of HbF greater than would be expected for their postconceptional age. The results suggest that cardiopulmonary insufficiency could stimulate HbF synthesis during the first year of life as a result of an erythropoietic response to hypoxemia.

Key Words: bronchopulmonary dysplasia • fetal hemoglobin synthesis • hypoxemia

Submitted on May 31, 1989
Accepted on August 15, 1989




This article has been cited by other articles:


Home page
 PediatricsHome page
H. Bard, A. Cote, J.-P. Praud, C. Infante-Rivard, and C. Gagnon
Fetal Hemoglobin Synthesis Determined by {gamma}-mRNA/{gamma}-mRNA + {beta}-mRNA Quantitation in Infants at Risk for Sudden Infant Death Syndrome Being Monitored at Home for Apnea
Pediatrics, October 1, 2003; 112(4): e285 - 285.
[Abstract] [Full Text] [PDF]